Seite - (000005) - in Biomedical Chemistry: Current Trends and Developments

Contents Preface Section 1: Chemical Principles in Drug Design and Discovery 1.1 Functional Groups of Biomolecules and their Reactions 1.1.1 Functional Groups in Biological Systems 1.1.2 Acids and Bases Versus Electrophiles and Nucleophiles 1.1.3 Stereoisomerism and Chirality 1.1.3.1 Cis/trans Isomerism 1.1.3.2 Chirality and Enantiomerism 1.1.4 Common Mechanisms in Biological Chemistry 1.1.4.1 Nucleophilic Substitution Reactions 1.1.4.1.1 SN2 – Bimolecular Nucleophilic Substitution 1.1.4.1.2 SN1 ‒ Unimolecular Nucleophilic Substitution Reactions 1.1.4.1.3 Phosphate Group Transfer – the Grey Area of Nucleophilic Substitutions in Biological Systems 1.1.4.2 Electrophilic Addition Reactions 1.1.4.2.1 Synthesis of α-Terpineol ‒ Intramolecular Addition 1.1.4.3 Aromatic Substitutions 1.1.4.3.1 Electrophilic Aromatic Substitution 1.1.4.3.2 Nucleophilic Aromatic Substitutions 1.1.4.3.3 Hallucinogen Synthesis ‒ Aromatic Substitution on