Seite - (000007) - in Biomedical Chemistry: Current Trends and Developments

1.1.5.5. FAD − a More Versatile Coenzyme 1.1.5.6 Biotin and Carboxylation Reactions References 1.2 Designing Covalent Inhibitors: A Medicinal Chemistry Challenge 1.2.1 Introduction 1.2.2 Designing Safer Covalent Inhibitors 1.2.3 Case Study 1: Michael Acceptors to Treat Infectious Diseases 1.2.3.1 K777 Inhibitor 1.2.3.2 Rupintrivir (AG7088) 1.2.4 Case Study 2: From Covalent Inhibitors to Hybrid Drugs 1.2.4.1 Hybrid Compounds Containing an Electrophilic Warhead 1.2.4.2 Hybrid Compounds Containing a Masked Electrophilic Warhead 1.2.5 Conclusions References Section 2: Chemical Basis of Drug Action and Diseases 2.1 Pharmacokinetics and Bioanalysis to Improve Drug Development Abbreviations 2.1.1 Introduction 2.1.2 Pharmacokinetic on Drug Discovery and Development