Seite - (000012) - in Biomedical Chemistry: Current Trends and Developments

3.2.6.2 Multiple Sclerosis (MS) 3.2.6.3 Alzheimer’s Disease (AD) 3.2.6.4 Huntington’s Disease (HD) 3.2.6.5 Stroke 3.2.6.6 Parkinson’s Disease 3.2.6.7 Traumatic Brain or Spinal Cord Injury 3.2.7 Why not Fully Block Calcium Entry via Pharmacological Agents? 3.2.8 Emerging Targets for Reducing Calcium-mediated Excitotoxicity 3.2.9 Conclusions and Outlook References 3.3 Strategies for Conversion of Peptides to Peptidomimetic Drugs 3.3.1 Peptides as Starting Points in Drug Discovery 3.3.1.1 Strategy for the Development of Peptidomimetics 3.3.1.1.1 Property Elucidation 3.3.1.1.2 Structure–Activity Relationship 3.3.1.1.3 Bioactive Conformation 3.3.1.1.3.1 Secondary Structure Mimetics 3.3.2 A Case study of Rational Peptide Lead Optimization: Development of Small and Constrained Peptides Targeting the Substance P 1-7 Binding site