Seite - (000056) - in Biomedical Chemistry: Current Trends and Developments

Scheme 1.1.39: Equation for the synthesis of ACV. Scheme 1.1.40: Mechanism for the synthesis of isopenicillin-N by the action of isopenicillin-N synthase. The isopenicillin-N may then proceed to be epimerised by isopenicillin- N epimerase (Scheme 1.1.41). This enzyme acts by α-deprotonation of the amino adipoyl moiety followed by protonation on the opposite side of the plane of the formed carboanion.