Seite - (000306) - in Biomedical Chemistry: Current Trends and Developments

a Rat liver membranes b Pig uterus myometrium γ-Turn Mimicking Scaffold D In the case of the γ-turn mimicking scaffold D (Fig. 3.3.7) an idealized γ- turn was first used to perform geometry comparison with respect to distances and angles in the turn structure. In scaffold D two amino acid residues corresponding to i+1 and i+2 can be directly mapped onto a peptide as seen in Fig. 3.3.7. The third atom building up the Cα atom triangle is part of a benzene ring, but is easily mapped to a peptide backbone via atom count either from the N-terminal or from residue i+1. As seen in Fig. 3.3.7 the Cα –Cα distances and angles match very well