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Alcantaraet al. Molecular imagingofbreast cancer Waterton, J. C., and Pylkkanen, L. (2012). Qualification of imaging biomark- ers for oncology drug development. Eur. J. Cancer 48, 409–415. doi: 10.1016/j.ejca.2011.11.037 Weissleder, R. (2006).Molecular imaging in cancer. Science 312, 1168–1171. doi: 10.1126/science.1125949 Yamaguchi, K., Abe, H., Newstead, G., Egashira, R., Nakazono, T., Imaizumi, T., et al. (2014). Intratumoral heterogeneity of the distribution of kinetic parameters in breast cancer: comparison based on the molecular subtypes of invasive breast cancer. Breast Cancer 1–7. doi: 10.1007/s12282-013- 0512-0. [Epubaheadofprint]. Yan,C.,Wu,Y., Feng, J.,Chen,W.,Liu,X.,Hao,P., et al. (2013).Anti-alphavbeta3 antibodyguided three-steppretargetingapproachusingmagnetoliposomes for molecular magnetic resonance imaging of breast cancer angiogenesis. Int. J. Nanomedicine8,245–255.doi:10.2147/IJN.S38678 Zhou, Z., and Lu, Z. R. (2013). Gadolinium-based contrast agents formagnetic resonance cancer imaging.Wiley Interdiscip. Rev.Nanomed.Nanobiotechnol.5, 1–18.doi:10.1002/wnan.1198 Conflict of Interest Statement:The authors declare that the research was con- ducted in the absence of any commercial or financial relationships that could be construedasapotential conflictof interest. Received: 15 October 2014; accepted: 01 December 2014; published online: 18 December2014. Citation:AlcantaraD, LealMP,García-Bocanegra I andGarcía-MartinML (2014) Molecular imagingofbreastcancer:presentandfuturedirections.Front.Chem.2:112. doi: 10.3389/fchem.2014.00112 Thisarticlewas submitted toChemicalEngineering,a sectionof the journalFrontiers inChemistry. Copyright © 2014 Alcantara,Leal,García-BocanegraandGarcía-Martin.This isan open-access article distributedunder the terms of theCreativeCommonsAttribution License (CCBY).Theuse, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are creditedand that the original publica- tion in this journal is cited, in accordance with accepted academic practice. No use, distributionor reproduction ispermittedwhichdoesnot complywith these terms. www.frontiersin.org December2014 |Volume2 |Article112 | 117