Seite - 124 - in Cancer Nanotheranostics - What Have We Learnd So Far?

Liuet al. AuNS forcancer imagingand therapy FIGURE1 | (A)TEM imagesof synthesizedAuNS (left), silica-coatedAuNS (middle), andsilver coated-AuNS (right). (B)CT (left) andMRI (right) imaging withdevelopedmultifunctionalAuNSnanoprobe. (C)Demonstrationof TAT-peptideenhancedTPL imaging,photodynamic therapy (PDT), and surface-enhancedRamanscattering (SERS) imagingafter 1-h incubation with theAuNSprobe.Scalebars forTPL,PDTandSERS imageare10,250, and20µm, respectively. (D)PET/CT imagingwith64Cu labeledAuNS probe,whichwas injected intravenously through tail vein.Dynamic imaging at various timepointeswereacquired.Arrowshows tumor (Faleset al., 2011,2013,2014;Yuanetal., 2013a;Liuet al., 2015b). Enlowetal.,1986;AlakandVo-Dinh,1987;Belloetal.,1989;Vo- Dinh et al., 1994, 2013; Stokes et al., 2004; Yuan et al., 2013a). SERRS AuNS nanoprobes have been developed to perform quantitative ex vivomultiplex detection with high sensitivity (Yuanet al., 2013b).TheAuNSnanoprobeshavealsobeenused for SERS imaging for cancer cells as shown inFigure1C (Fales Frontiers inChemistry |www.frontiersin.org August2015 |Volume3 |Article51 124|