Page - (000008) - in Biomedical Chemistry: Current Trends and Developments

Process 2.1.2.1 ADME/Pharmacokinetic Evaluation on Early Drug Discovery Phases 2.1.2.2 Pharmacokinetic Evaluation on Drug Development Phases 2.1.3 Bioanalysis and Validation Requirements on DDD 2.1.4 Bioanalysis & Pharmacokinetics, a Synergistic Partnership on DDD 2.1.4.1 Bioanalytic Support of In Vitro ADME Studies 2.1.4.2 Bioanalytic Support of In Vivo ADME/Pharmacokinetic Studies 2.1.5 Conclusions References 2.2 Translational Research in Endocrinology and Neuroimmunology Applied to Depression 2.2.1 Major Depressive Disorder 2.2.2 The Stress Response 2.2.2.1 The CRH System and the Stress Response 2.2.2.2 The Locus Ceruleus Norepinephrine (LC-NE) System and Other Central Nervous System (CNS) Structures that Modulate the Stress System 2.2.2.3 The Immune System 2.2.3 The Effect of Chronic Stress and MDD in Dysregulating the Core Stress System