Page - (000082) - in Biomedical Chemistry: Current Trends and Developments

Ana Fortuna, Gilberto Alves, Amílcar Falcão 2.1 Pharmacokinetics and Bioanalysis to Improve Drug Development Abbreviations ADME – absorption, distribution, metabolism and excretion; APCI – atmospheric pressure chemical ionization; AUC – area under the drug concentration-time curve; BA/BE – bioavailability/bioequivalence; BCRP − breast cancer resistance protein; Caco-2 − human colon adenocarcinoma cell line; CL − clearance; Cmax − maximum concentration; CV − coefficient of variation; CYP − cytochrome P450; DDD − drug discovery and development; DDI − drug-drug interactions; EMA − European Medicines Agency; ESI − electrospray ionization; FDA − Food and Drug Administration; GC − gas chromatography; HPLC − high performance liquid chromatography; HTS − high-throughput screening; ICH − International Conference on Harmonisation; IS − internal standard