Page - (000083) - in Biomedical Chemistry: Current Trends and Developments

LC − liquid chromatography; LLE − liquid-liquid extraction; LLOQ − lower limit of quantification; LOD − limit of detection MDCK − Madin-Darby canine kidney cell line; MIST − metabolites in safety testing; MRM − multiple-reaction monitoring MS − mass spectrometry; MS/MS − tandem mass spectrometry; NCEs − new chemical entities; PAMPA − parallel artificial membrane permeability assay; Papp − apparent permeability; PepT1 − oligopeptide transporter; QC − quality control; Q-TOF − quadrupole coupled with time-of-flight mass analyzer; RE − relative error; RSD − relative standard deviation; SIM − selective ion monitoring; SPE − solid-phase extraction; SRM − single-reaction monitoring; t1/2 − elimination half-life; TDM − therapeutic drug monitoring; tmax − time to reach the Cmax; UGT − UDP glucuronosyltransferase; UHPLC − ultra-high pressure liquid chromatography; UV − ultraviolet;