Page - (000259) - in Biomedical Chemistry: Current Trends and Developments

often be highly specific. Chemical strategies can improve the in vivo plasma residence time and, after that, introduce new peptides as drugs in the market. This way, the commercial value of peptides therapeutic will be well-established. Acknowledgments: Fundação para a Ciência e Tecnolgia (FCT, Portugal) for financial support through IF00092/2014, UID/Multi/04378/2013 projects, and for holding an IF position 00092/2014. Thanks are further due to ON.2 and FCUP for co-funding refurbishment of the Porto Peptide Synthesis Facility (POP-UP) through operation NORTE-07-0162-FEDER-000111. NV is also grateful to all authors that sharing their works and Dr. Mariana Barbosa (U. Porto) by it’s participation in “Peptides: Scaffolding materials in Tissue Engineering”. References Agerberth, B.; Charo, J.; Werr, J.; Olsson, B.; Idali, F.; Lindbom, L.; Kiessling, R.; Jornvall, H.; Wigzell, H.; Gudmundsson, G. H. (2000). The human antimicrobial and chemotactic peptides ll-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations. Blood, 96, 3086-3093. Aggeli, A.; Bell, M.; Carrick, L. M.; Fishwick, C. W.; Harding, R.; Mawer, P. J.; Radford, S. E.; Strong, A. E.; Boden, N. (2003). pH as a trigger of peptide β-sheet self-assembly and reversible switching between nematic and isotropic phases. Journal of the American Chemical Society, 125, 9619-9628. Aizawa, Y.; Owen, S. C.; Shoichet, M. S. (2012). Polymers used to influence cell fate in 3D geometry: new trends. Progress in Polymer Science, 37, 645-658. Andaloussi, S. E.; Lehto, T.; Mäger, I.; Rosenthal-Aizman, K.; Oprea, I. I.; Simonson, O. E.; Sork, H.; Ezzat, K.; Copolovici, D. M.; Kurrikoff, K.; Viola, J. R.; Zaghloul, E. M.; Sillard, R.; Johansson, H. J.; Hassane, F. S.; Guterstam, P.; Suhorutsenko, J.; Moreno, P. M.; Oskolkov, N.; Hälldin, J.; Tedebark, U.; Metspalu, A.; Lebleu, B.; Lehtiö, J.; Smith, C. I.; Langel, Ü. (2011). Design of a peptide-based vector, PepFect6, for efficient delivery of siRNA in cell culture and systemically in vivo. Nucleic Acids Research, 39, 3972-3987. Angeles-Boza, A. M.; Erazo-Oliveras, A.; Lee, Y. J.; Pellois, J. P. (2010). Beneration of endosomolytic reagents by branching of cell-penetrating peptides: tools for the delivery of bioactive compounds to live cells in cis or trans. Bioconjugate Chemistry, 21, 2164-2167. Araújo, M. J.; Bom, J.; Capela, R.; Casimiro, C.; Chambel, P.; Gomes, P.; Iley, J.; Lopes, F.; Morais, J.; Moreira, R.; Oliveira, E.; Rosário, V.; Vale, N. (2005). Imidazolidin-4-one derivatives of primaquine as novel transmission-blocking antimalarials. Journal of Medicinal Chemistry, 48, 888-892. Ashley, E. A.; Recht, J.; White, N. J. (2014). Primaquine: the risks and the benefits. Malaria