Page - (000369) - in Biomedical Chemistry: Current Trends and Developments

the larger ones were mostly restrained inside the blood vessels. Figure 3.5.8: Histological data of the nanoparticle uptake in tumors when different sized nanoparticles were used in vivo. Reproduced with permission from (Perrault, 2009). In a study conducted by Tseng, magnetothermally-responsive doxorubicin loaded supramolecular magnetic nanoparticles (Dox- SMNPs) were synthesized with the sizes of 70, 100 and 160 nm, and subsequently injected intravenously into DLD-1 colorectal adenocarcinoma tumor bearing mice, aiming to examine the influence of the nanoparticles’ size on their retention at the tumor site (Jain, 1987). The two-dimension (2D) micro-positron emission tomography (PET) cross sectional images displayed a considerably higher accumulation of the 70 nm nanoparticles at the malignant tissue, comparatively to their larger counterparts (Fig. 3.5.9).