Page - (000396) - in Biomedical Chemistry: Current Trends and Developments

bedside translation of the nanomedicines and technologies have introduced a new era in the design and development of innovative but simultaneously complex targeting nanoparticles for delivery of therapeutic and diagnostic agents to tumors. Accordingly, despite the great versatility and promising features observed for such anticancer therapeutic systems, intensive research studies are still needed at the pre-clinical level in order to develop nano-formulations that can be produced in large scale and applied in the clinic. Acknowledgments: The Academy of Finland (projects numbers 252215 and 281300), The University of Helsinki Research Funds, The Biomedicum Centrum, The European Research Council under the European Union’s Seventh Framework Programme (FP7/2007-2013) ERC Starting Grant no. 310892, The Drug Research Doctoral Programme of the Faculty of Pharmacy, University of Helsinki, and The Finnish Cultural Foundation (grant no. 00130129) are acknowledge for financial support. References ACS. (2014). Cancer. American Cancer Society, Retrieved 27th October 2014, from http://www.cancer.org/. Alexis, F., Pridgen, E., Molnar, L. K., et al. (2008). Factors affecting the clearance and biodistribution of polymeric nanoparticles. Molecular Pharmaceutics, 5(4), 505-515. Allen, T. M. (2002). Ligand-targeted therapeutics in anticancer therapy. Nature Reviews Cancer, 2(10), 750-763. Almeida, J. P., Figueroa, E. R., Drezek, R. A. (2014). Gold nanoparticle mediated cancer immunotherapy. Nanomedicine, 10(3), 503-514. Ananta, J. S., Godin, B., Sethi, R., et al. (2010). Geometrical confinement of gadolinium-based contrast agents in nanoporous particles enhances t1 contrast. Nature Nanotechnol, 5(11), 815-821. Anglin, E. J., Cheng, L., Freeman, W. R., et al. (2008). Porous silicon in drug delivery devices and materials. Advanced Drug Delivery Reviews, 60(11), 1266-1277. Annabi, N., Tamayol, A., Uquillas, J. A., et al. (2014). 25th anniversary article: Rational design and applications of hydrogels in regenerative medicine. Advanced Materials, 26(1), 85-123. Ansari, C., Tikhomirov, G. A., Hong, S. H., et al. (2014). Development of novel tumor-targeted theranostic nanoparticles activated by membrane-type matrix metalloproteinases for combined cancer magnetic resonance imaging and therapy. Small, 10(3), 566-575, 417. Arias, J. L. (2011). Drug targeting strategies in cancer treatment: An overview. Mini-Reviews in Medicinal Chemistry, 11(1), 1-17.