Page - 28 - in Advances in Neuroimmunology

BrainSci. 2016,6, 15 25. Campbell, I.L.; Abraham, C.R.; Masliah, E.; Kemper, P.; Inglis, J.D.; Oldstone, M.B.A.; Mucke, L. Neurologicdisease in transgenicmicebycerebraloverexpressionof interleukin6.Proc.Natl. Acad. Sci.USA 1993,90, 10061–10065. [CrossRef] [PubMed] 26. Campbell, I.L.;Erta,M.;Lim,S.L.;Frausto,R.;May,U.;Rose-John,S.;Scheller, J.;Hidalgo,J.Trans-signaling is adominantmechanismforthepathogenicactionsofinterleukin-6inthebrain. J.Neurosci.2014,34,2503–2513. [CrossRef] [PubMed] 27. Costantino,C.M.;Baecher-Allan,C.;Hafler,D.A.MultiplesclerosisandregulatoryTcells. J.Clin. Immunol. 2008,28, 697–706. [CrossRef] [PubMed] 28. Kimura,A.; Kishimoto, T. Il-6: Regulator of Treg/Th17 balance. Eur. J. Immunol. 2010, 40, 1830–1835. [CrossRef] [PubMed] 29. Murphy,A.C.;Lalor,S.J.;Lynch,M.A.;Mills,K.H.Infiltrationofth1andTh17cellsandactivationofmicroglia in theCNSduringthecourseofexperimentalautoimmuneencephalomyelitis.BrainBehav. Immun. 2010,24, 641–651. [CrossRef] [PubMed] 30. Bettelli, E.; Carrier, Y.; Gao, W.; Korn, T.; Strom, T.B.; Oukka, M.; Weiner, H.L.; Kuchroo, V.K. Reciprocaldevelopmentalpathwaysfor thegenerationofpathogeniceffectorTh17andregulatoryTcells. Nature2006,441, 235–238. [CrossRef] [PubMed] 31. Korn, T.; Mitsdoerffer, M.; Croxford, A.L.; Awasthi, A.; Dardalhon, V.A.; Galileos, G.; Vollmar, P.; Stritesky,G.L.; Kaplan,M.H.;Waisman,A.; et al. IL-6 controls Th17 immunity invivoby inhibiting the conversionof conventional t cells into Foxp3+ regulatoryT cells. Proc. Natl. Acad. Sci. USA 2008, 105, 18460–18465. [CrossRef] [PubMed] 32. Ma,X.;Reynolds,S.L.;Baker,B.J.;Li,X.;Benveniste,E.N.;Qin,H. IL-17enhancementof the IL-6signaling cascade inastrocytes. J. Immunol. 2010,184, 4898–4906. [CrossRef] [PubMed] 33. Ogura,H.; Murakami,M.; Okuyama, Y.; Tsuruoka,M.; Kitabayashi, C.; Kanamoto,M.; Nishihara,M.; Iwakura,Y.;Hirano,T. Interleukin-17promotesautoimmunitybytriggeringapositive-feedback loopvia interleukin-6 induction. Immunity2008,29, 628–636. [CrossRef] [PubMed] 34. Swartz,K.R.; Liu, F.; Sewell,D.; Schochet, T.; Campbell, I.; Sandor,M.; Fabry,Z. Interleukin-6promotes post-traumatichealing in thecentralnervoussystem.BrainRes. 2001,896, 86–95. [CrossRef] 35. Fee,D.;Grzybicki,D.;Dobbs.,M.; Ihyer, S.; Clotfelter, J.;Macvilay, S.;Hart,M.N.; Sandor,M.; Fabry,Z. Interleukin 6promotes vasculogenesis ofmurine brainmicrovessel endothelial cells. Cytokine 2000, 12, 655–665. [CrossRef] [PubMed] ©2016bytheauthors. LicenseeMDPI,Basel,Switzerland. Thisarticle isanopenaccess articledistributedunder the termsandconditionsof theCreativeCommonsAttribution (CCBY) license (http://creativecommons.org/licenses/by/4.0/). 28