Seite - 50 - in Advances in Neuroimmunology

BrainSci. 2016,6, 18 58. Nam, J.H.; Park,K.W.; Park,E.S.; Lee,Y.B.; Lee,H.G.; Baik,H.H.;Kim,Y.S.;Maeng, S.; Park, J.; Jin,B.K. Interleukin-13/-4-inducedoxidativestresscontributes todeathofhippocampalneurons inaβ1-42-treated hippocampus invivo.Antioxid. RedoxSignal. 2012,16, 1369–1383. [CrossRef] [PubMed] 59. Park, K.W.; Baik,H.H.; Jin, B.K. Interleukin-4-induced oxidative stress viamicroglialNADPHoxidase contributes to thedeath of hippocampal neurons invivo. Curr. Aging Sci. 2008, 1, 192–201. [CrossRef] [PubMed] 60. Park,K.W.;Baik,H.H.; Jin,B.K. IL-13-inducedoxidativestressviamicroglialNADPHoxidasecontributes to deathofhippocampalneurons invivo. J. Immunol. 2009,183, 4666–4674. [CrossRef] [PubMed] 61. Yadav,M.C.;Burudi,E.M.;Alirezaei,M.;Flynn,C.C.;Watry,D.D.;Lanigan,C.M.;Fox,H.S. IFN-gamma-induced IDOandWRSexpression inmicroglia isdifferentially regulatedbyIL-4.Glia2007,55, 1385–1396. [CrossRef] [PubMed] 62. Clarke,R.M.;Lyons,A.;O’Connell,F.;Deighan,B.F.;Barry,C.E.;Anyakoha,N.G.;Nicolaou,A.;Lynch,M.A. Apivotal role for interleukin-4 inatorvastatin-associatedneuroprotection inratbrain. J.Biol. Chem. 2008, 283, 1808–1817. [CrossRef] [PubMed] 63. Deboy,C.A.;Xin, J.;Byram,S.C.;Serpe,C.J.; Sanders,V.M.; Jones,K.J. Immune-mediatedneuroprotectionof axotomizedmouse facialmotoneurons isdependentonthe IL-4/STAT6signalingpathwayinCD4(+)Tcells. Exp.Neurol. 2006,201, 212–224. [CrossRef] [PubMed] 64. Rossi,S.;Mancino,R.;Bergami,A.;Mori,F.;Castelli,M.;DeChiara,V.;Studer,V.;Mataluni,G.;Sancesario,G.; Parisi,V.; et al. Potential role of IL-13 inneuroprotectionandcortical excitability regulation inmultiple sclerosis.Mult. Scler. J.2011,17, 1301–1312. [CrossRef] [PubMed] 65. Won,S.Y.;Kim,S.R.;Maeng,S.; Jin,B.K. Interleukin-13/Interleukin-4-inducedoxidativestresscontributes to deathofprothrombinkringle-2 (pKr-2)-activatedmicroglia. J.Neuroimmunol. 2013,265, 36–42. [CrossRef] [PubMed] 66. Bluthe,R.M.;Lestage, J.;Rees,G.;Bristow,A.;Dantzer,R.Dualeffectofcentral injectionof recombinant rat interleukin-4onlipopolysaccharide-inducedsicknessbehavior inrats.Neuropsychopharmacology2002,26, 86–93. [CrossRef] 67. Linker,R.A.;Sendtner,M.;Gold,R.Mechanismsofaxonaldegeneration inEAE—Lessons fromCNTFand MHCIknockoutmice. J.Neurol. Sci. 2005,233, 167–172. [CrossRef] [PubMed] 68. Zeis,T.;Graumann,U.;Reynolds,R.; Schaeren-Wiemers,N.Normal-appearingwhitematter inmultiple sclerosis is in a subtle balance between inflammation and neuroprotection. Brain 2008, 131, 288–303. [CrossRef] [PubMed] 69. Seyfizadeh,N.;Kazemi,T.;Farhoudi,M.;RezaAliparasti,M.;Sadeghi-Bazargani,H.;Almasi,S.;Babaloo,Z. Associationof IL-13singlenucleotidepolymorphismsinIranianpatients tomultiplesclerosis.Am. J.Clin. Exp. Immunol. 2014,3, 124–129. [PubMed] 70. Rozsa,K.S.; Rubakhin, S.S.; Szucs,A.;Hughes, T.K.; Stefano,G.B.Opposite effects of interleukin-2 and interleukin-4onGABA-induced inwardcurrentsofdialysed lymnaeaneurons.Gen. Pharmacol. 1997,29, 73–77. [CrossRef] 71. Sanna, A.; Fois,M.L.; Arru, G.; Huang, Y.M.; Link,H.; Pugliatti,M.; Rosati, G.; Sotgiu, S. Glatiramer acetatereduces lymphocyteproliferationandenhances IL-5andIL-13productionthroughmodulationof monocyte-deriveddendriticcells inmultiplesclerosis.Clin. Exp. Immunol. 2006,143, 357–362. [CrossRef] [PubMed] 72. Cash,E.;Minty,A.;Ferrara,P.;Caput,D.;Fradelizi,D.;Rott,O.Macrophage-inactivatingIL-13suppresses experimentalautoimmuneencephalomyelitis inrats. J. Immunol. 1994,153, 4258–4267. [PubMed] 73. Offner,H.;Subramanian,S.;Wang,C.;Afentoulis,M.;Vandenbark,A.A.;Huan, J.;Burrows,G.G.Treatment ofpassiveexperimentalautoimmuneencephalomyelitis inSJLmicewitharecombinantTCRligandinduces IL-13andpreventsaxonal injury. J. Immunol. 2005,175, 4103–4111. [CrossRef] [PubMed] 74. Young,D.A.;Lowe,L.D.;Booth,S.S.;Whitters,M.J.;Nicholson,L.;Kuchroo,V.K.;Collins,M. IL-4, IL-10, IL-13,andTGF-β fromanalteredpeptide ligand-specificTh2cell clonedown-regulateadoptive transferof experimentalautoimmuneencephalomyelitis. J. Immunol. 2000,164, 3563–3572. [CrossRef] [PubMed] 75. Ochoa-Repáraz, J.; Rynda,A.;Ascón,M.A.; Yang,X.;Kochetkova, I.; Riccardi,C.; Callis,G.; Trunkle, T.; Pascual, D.W. IL-13 production by regulatory T cells protects against experimental autoimmune encephalomyelitis independentlyofautoantigen. J. Immunol. 2008,181, 954–968. [CrossRef] [PubMed] 76. Compston,A.;Coles,A.Multiplesclerosis.Lancet2008,372, 1502–1517. [CrossRef] 50