Seite - 34 - in Cancer Nanotheranostics - What Have We Learnd So Far?

Condeetal. Biofunctionalizationandsurfacechemistryof inorganicnanoparticles Yang,Y.,Cui,X.K.,Zhong,M.,andLi,Z. J. (2012a).Studyofcarbohydrate-protein interactionsusingglyco-QDswithdifferentfluorescenceemissionwavelengths. Carbohydr.Res.361,189–194.doi:10.1016/j.carres.2012.08.018 Yang,Y., Lan, J., Xu,Z.,Chen,T., Zhao,T.,Cheng,T., et al. (2012b).Toxicity and biodistribution of aqueous synthesized ZnS and ZnOquantumdots inmice. Nanotoxicology8,107–116.doi:10.3109/17435390.2012.760014 Ye, M., Zhang, Y. Y., Li, H. T., Zhang, Y. Q., Tan, P., Tang, H., et al. (2009). A novel method for the detection of point mutation in DNA using single-base-coded CdS nanoprobes. Biosens. Bioelectron. 24, 2339–2345. doi: 10.1016/j.bios.2008.12.002 Yezhelyev,M.V.,Qi,L.F.,O’Regan,R.M.,Nie, S., andGao,X.H. (2008).Proton- sponge coated quantum dots for siRNA delivery and intracellular imaging. J.Am.Chem.Soc.130,9006–9012.doi:10.1021/ja800086u Yoo, D., Lee, J. H., Shin, T. H., and Cheon, J. (2011). Theranostic magnetic nanoparticles.Acc.Chem.Res.44,863–874.doi:10.1021/ar200085c Zhang,B.B.,Cheng,J.,Li,D.N.,Liu,X.H.,Ma,G.P.,andChang,J.(2008).Anovel methodtomakehydrophilicquantumdotsanditsapplicationonbiodetection. Mater.Sci.Eng.BAdv.149,87–92.doi:10.1016/j.mseb.2007.12.009 Zhang,C.Y.,andHu,J. (2010).Singlequantumdot-basednanosensorformultiple DNAdetection.Anal.Chem.82,1921–1927.doi:10.1021/ac9026675 Zhang,C.Y.,Yeh,H.C.,Kuroki,M.T., andWang,T.H. (2005a).Single-quantum- dot-basedDNAnanosensor.Nat.Mater.4,826–831.doi:10.1038/nmat1508 Zhang, P. F., Liu, S. H., Gao, D. Y., Hu, D. H., Gong, P., Sheng, Z. H., et al. (2012a). Click-functionalized compact quantum dots protected by multidentate-imidazole ligands: conjugation-ready nanotags for living-virus labelingandimaging. J.Am.Chem.Soc.134,8388–8391.doi:10.1021/ja302367s Zhang, S. X., Wang, N., Yu, H. J., Niu, Y. M., and Sun, C. Q. (2005b). Covalent attachmentof glucoseoxidase to anAuelectrodemodifiedwithgold nanoparticles for use as glucose biosensor.Bioelectrochemistry 67, 15–22. doi: 10.1016/j.bioelechem.2004.12.002 Zhang, T., Wu, Y. P., Pan, X. M., Zheng, Z. H., Ding, X. B., and Peng, Y. X. (2009).AnapproachforthesurfacefunctionalizedgoldnanoparticleswithpH- responsivepolymerbycombinationofRAFTandclickchemistry.Eur.Polym.J. 45,1625–1633.doi:10.1016/j.eurpolymj.2009.03.016 Zhang, X., Servos, M. R., and Liu, J. (2012b). Surface science of DNA adsorp- tion onto citrate-capped gold nanoparticles. Langmuir 28, 3896–3902. doi: 10.1021/la205036p Zhao, E. Y., Zhao, Z. X.,Wang, J. C., Yang, C. H., Chen, C. J., Gao, L. Y., et al. (2012a). Surface engineeringof goldnanoparticles for in vitro siRNAdelivery. Nanoscale4,5102–5109.doi:10.1039/c2nr31290e Zhao,Q.,Wang,L.N.,Cheng,R.,Mao,L.D.,Arnold,R.D.,Howerth,E.W., et al. (2012b).Magneticnanoparticle-basedhyperthermia forhead&neckcancer in mousemodels.Theranostics2,113–121.doi:10.7150/thno.3854 Zhao,Y.,Zhao,L. J.,Zhou,L. J.,Zhi,Y.,Xu, J.M.,Wei,Z., et al. (2010).Quantum dot conjugates for targeted silencing of bcr/abl gene by RNA interference in human myelogenous leukemia K562 cells. J. Nanosci. Nanotechnol. 10, 5137–5143.doi:10.1166/jnn.2010.2396 Zhou,D.J.,Ying,L.M.,Hong,X.,Hall,E.A.,Abell,C.,andKlenerman,D.(2008a). A compact functional quantum dot-DNA conjugate: preparation, hybridiza- tion, and specific label-free DNA detection. Langmuir 24, 1659–1664. doi: 10.1021/la703583u Zhou,M.,Nakatani, E., Gronenberg, L. S., Tokimoto, T.,Wirth,M. J., Hruby, V. J., et al. (2007). Peptide-labeled quantum dots for imaging GPCRs in whole cells and as single molecules. Bioconjug. Chem. 18, 323–332. doi: 10.1021/ bc0601929 Zhou, Y., Wang, S. X., Zhang, K., and Jiang, X. Y. (2008b). Visual detec- tion of copper(II) by azide- and alkyne-functionalized gold nanoparticles using click chemistry. Angew. Chem. Int. Ed. Engl. 47, 7454–7456. doi: 10.1002/anie.200802317 Zhu, J.,Waengler, C., Lennox, R. B., and Schirrmacher, R. (2012a). Preparation of water-soluble maleimide-functionalized 3nm gold nanoparticles: a new bioconjugation template. Langmuir 28, 5508–5512. doi: 10.1021/ la300316j Zhu, K., Zhang, Y., He, S., Chen, W.W., Shen, J. Z., Wang, Z., et al. (2012b). Quantification of proteins by functionalized gold nanoparticles using click chemistry.Anal.Chem.84,4267–4270.doi:10.1021/ac3010567 Zuo,G.,Huang,Q.,Wei,G.,Zhou,R.,andFang,H.(2010).Pluggingintoproteins: poisoning protein function by a hydrophobic nanoparticle. ACS Nano 4, 7508–7514.doi:10.1021/nn101762b Conflict of Interest Statement:The authors declare that the research was con- ducted in the absence of any commercial or financial relationships that could be construedasapotential conflictof interest. Received:24April2014;accepted:24 June2014;publishedonline:15 July2014. Citation: Conde J, Dias JT, Grazú V,MorosM, Baptista PV and de la Fuente JM (2014)Revisiting 30 years of biofunctionalizationand surface chemistry of inorganic nanoparticles fornanomedicine.Front.Chem.2:48.doi:10.3389/fchem.2014.00048 Thisarticlewas submitted toChemicalEngineering,a sectionof the journalFrontiers inChemistry. Copyright © 2014 Conde,Dias,Grazú,Moros,Baptistaandde laFuente.This is an open-access article distributedunder the terms of theCreativeCommonsAttribution License (CCBY).Theuse, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are creditedand that the original publica- tion in this journal is cited, in accordance with accepted academic practice. No use, distributionor reproduction ispermittedwhichdoesnot complywith these terms. www.frontiersin.org July2014 |Volume2 |Article48 | 34