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Condeetal. Biofunctionalizationandsurfacechemistryof inorganicnanoparticles
FIGURE7 |Goldglyconanoparticles. (A)Strategy for studying
carbohydrate±carbohydrate interactionsbasedon2Dand3Dmodels that
mimiccarbohydratepresentationat thecell surface.Preparationof (B)glyconanoparticles; (C)hybridglyconanoparticles; (D)fluorescence
glyconanoparticles (Barrientoset al., 2003).Reproducedwithpermission
fromBarrientoset al. (2003),Copyright2013.
stabilityoftheNP,thefunctionalgroups, thebioconjugationcon-
ditions(pH,temperature, ionicstrength,solventchoice,structure
of the surfactant) and the biomolecule to attach, among others.
Finally,dependingontheconjugatedbiomolecule, it is important tocontrol theorientation, so that thebiomolecule remainsactive
onceconjugated to theNP.
Biofunctionalizationcanbeachievedusingseveral techniques,
such as physical adsorption and electrostatic binding, specific
www.frontiersin.org July2014 |Volume2 |Article48 | 20
Cancer Nanotheranostics
What Have We Learnd So Far?
- Title
- Cancer Nanotheranostics
- Subtitle
- What Have We Learnd So Far?
- Authors
- João Conde
- Pedro Viana Baptista
- Jesús M. De La Fuente
- Furong Tian
- Editor
- Frontiers in Chemistry
- Date
- 2016
- Language
- English
- License
- CC BY 4.0
- ISBN
- 978-2-88919-776-7
- Size
- 21.0 x 27.7 cm
- Pages
- 132
- Keywords
- Nanomedicine, Nanoparticles, nanomaterials, Cancer, heranostics, Immunotherapy, bioimaging, Drug delivery, Gene Therapy, Phototherapy
- Categories
- Naturwissenschaften Chemie