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CHAPTER1
Introduction
The investigation of charge transfer processes constitutes an interface between
physics, chemistry and biology. Chemical reactions are often accompanied by
chargetransferprocessesnotonly inthe laboratory,butalso inbiologicalprocesses.
Here,DNAoccupiesanoutstandingposition intheresearcherscommunity. Itsnat-
ural feature to support charge transfer is seen in processes like radiative damage
andrepairofDNAstrands in livingorganisms. In the lastyears, theevolvingďŹeld
ofmolecular electronicshasbroughtDNAinto the focusasapotential element for
electronic circuits at the molecular scale. Special features like self-assembly and
self-recognitionare aunique characteristic ofDNAoligomers.
The conductivity of DNA has been studied intensively in the recent years.[1, 2]
Yet, there are still features of charge transport (CT) that have not been resolved
unambiguously yet. The research of CT in nucleic acids started with measure-
mentsperformedon longDNAstrandsof several thousandbasepairs, in the form
of âropesâ[3] or on supercoiledDNA.[4] In these early times, diametrically differ-
ent conductivity of DNA under different conditions was reported, ranging from
superconductivity[5] to insulation.[6]
ThepioneeringstudyofCTin individualDNAoligomersappeared in2000,[7] and
several further single-molecule experiments have been reported since then.[8â13]
All of these studies are in aqualitative agreementupon the semi-conducting char-
5
Charge Transport in DNA
Insights from Simulations
- Title
- Charge Transport in DNA
- Subtitle
- Insights from Simulations
- Author
- Mario Wolter
- Publisher
- KIT Scientific Publishing
- Date
- 2013
- Language
- English
- License
- CC BY-SA 3.0
- ISBN
- 978-3-7315-0082-7
- Size
- 17.0 x 24.0 cm
- Pages
- 156
- Keywords
- Charge Transport, Charge Transfer, DNA, Molecular Dynamics, Quantum Mechanics
- Categories
- Naturwissenschaften Chemie
Table of contents
- Zusammenfassung 1
- Summary 3
- 1 Introduction 5
- 2 TheoreticalBackground 11
- 3 SimulationSetup 39
- 4 DNAUnderExperimentalConditions 49
- 5 ChargeTransport inStretchedDNA 69
- 6 ChargeTransport inMicrohydratedDNA 79
- 7 AParametrizedModel toSimulateCT inDNA 89
- 8 Conclusion 105
- Appendix 111
- A DNAUnderExperimentalConditions 111
- B CTinMicrohydratedDNA 117
- List ofPublications 137