Page - 77 - in Charge Transport in DNA - Insights from Simulations

5.5Conclusion These results provide ameans for the interpretation of the outcomeof conductiv- ityexperimentswhere theDNAmolecule isstretched,providedtheDNAsequence contains pyrimidine–purine steps,which is actually the case in thementioned ex- periments. The accumulated knowledge makes it possible to construct DNA se- quences such that theextent towhich their conductivity is affectedby themechan- ical stress during the experiments is controlled. The suggestion forDNA species attached with its 3’-ends to the electrodes would be to avoid pyrimidine–purine steps in the nucleobase sequence. Suitable DNA sequences can be opted for in thedesignofDNA-baseddevices asnano-scale electronic elements,where limited dependenceof conductivityon length isdesirable. 77